In the landscape of drug development, the handling of highly potent APIs (HPAPIs) has increasing significance. These compounds, characterized by their substantial pharmacological activity at exceptionally low doses, redefine the traditional paradigms of therapeutic intervention. By facilitating higher precision in dosing and attenuating undesired side effects, HPAPIs hold the potential to elevate drug efficacy to unprecedented levels. This Q&A with our expert Rob Abbenhuis, CHEM Division Manager at Ardena, explains the importance of effective HPAPI management in drug development, intertwining scientific advancement with the imperative of ensuring the well-being of personnel involved in these operations. The document provides a detailed exploration of Ardena’s meticulous approach to HPAPI handling, showcasing our commitment to both scientific rigor and safety.