Bioavailability enhancement

Bioavailability enhancement

Our science-led approach to improving bioavailability in formulation saves you time, money and clinical drug substance and materials.

Solving your solubility challenge efficiently

We help solve solubility challenges that impact your drug candidate’s reproducible absorption in the gastrointestinal tract. Where poor drug substance solubility limits oral bioavailability, we have dedicated technologies and expertise to apply formulation techniques that increase dissolution rate and/or apparent solubility at the absorption site.

We use screening to identify the most effective formulation technology for your compound, developed in our formulation laboratory and with facilities engineered to ensure a seamless transition to GMP manufacturing.

With a range of solubility-enhancing methods and technologies, our approach optimizes project timelines and quality while minimizing costs and risks.

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Solid dispersions

Solid dispersions

Amorphous solid dispersions increase solubility by eliminating the impact of crystal lattice energy on the dissolution process.

The physical stabilization of the amorphous state of the drug substance is accomplished via dispersion in a polymer matrix. We identify polymers with sufficient solid-state miscibility with the drug substance to prevent recrystallization and ensure consistent performance over time via a combined approach of precipitation assays and solvent evaporation trials, both conducted at a milligram scale.

Formulation concepts with adequate performance and physical stability are subsequently scaled-up and GMP-produced via spray drying or bead coating.

We provide a comprehensive solution to your solubility, stability and bioavailability problems by combining experience and capabilities in formulation, analytical and process development and technologies including spray drying. We also have suites capable of handling highly potent active substances.

Our Spray Drying technologies are suitable for a range of target molecules and provide a number of advantages:

  • Scalable and cost-effective technique
  • Rapid, continuous, repeatable process
  • Control of particle size and morphology
  • Ability to handle temperature-sensitive molecules

Lipid-based formulations

Lipid-based formulations

Lipid-based delivery systems range from simple oil solutions to complex mixtures of oils, surfactants, co-surfactants and co-solvents. These formulations present the drug substance to the body in a pre-dissolved state and increase oral bioavailability primarily by enhancing the solubilizing capacity of the gastrointestinal environment.

The wide variety of lipophilic excipients available and the intricacy of their interplay may render lipid formulation development complex.

We develop lipid formulations with a science-based approach that balances solubilizing capacity, in vitro performance and manufacturability.

Nanosuspensions

Nanosuspensions

Nanosuspensions show accelerated dissolution rates as a result of reducing the particle size, which leads to an increased surface area of these particles.

The key to nanosuspension development is the identification of a suitable stabilizer system, such that crystal growth and agglomeration effects are suppressed during the lifetime of the formulation.

In addition to a broad range of milling systems, we have the technologies to convert (liquid) nanosuspensions into solid forms.

Related resources

Our team members share their deep, scientific understanding and insights into bioavailability enhancement.

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On-demand webinar: Navigating CMC requirements for Spray Drying Processes
Webinars

On-demand webinar: Navigating CMC requirements for Spray Drying Processes

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# Bioavailability Enhancement CMC Regulatory
Formulation and Process Considerations for Optimising Spray-Dried Solid Dispersions
Whitepapers

Formulation and Process Considerations for Optimising Spray-Dried Solid Dispersions

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# Bioavailability Enhancement Drug Product
Which solubility-enhancing technology should I use to support my early drug development project?
Whitepapers

Which solubility-enhancing technology should I use to support my early drug development project?

Read more
# Bioavailability Enhancement Drug Product

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Our integrated platforms

Program management

Using the right standards at the right development phase, our comprehensive program management services streamline your small molecule drug development.

Drug substance

Helping you turn your compounds that show promise into GMP-grade drug substances.

Drug product

We advance your clinical candidates through the pipeline quickly and safely with specialist drug product services.

Bioanalysis

Our bioanalytical platform supports your preclinical and clinical stages with expert testing services.

CMC regulatory services

Our comprehensive CMC regulatory services streamline preparation and submission of your registration file.

Program management

Using the right standards at the right development phase, our comprehensive program management services streamline your large molecule drug development.

Drug product

We advance your large molecule candidates through the pipeline quickly and safely with specialist drug product services.

Bioanalysis

Our bioanalytical platform supports your large molecule drugs through preclinical and clinical stages with expert testing services.

CMC regulatory services

Our comprehensive CMC regulatory services streamline the preparation and submission of the regulatory files for your large molecule drug.

Program management

Using the right standards at the right development phase, our comprehensive program management services streamline your nanomedicine drug development.

Drug product

We turn your nanomedicine candidates into suitable drugs with specialist development and manufacturing services.

Bioanalysis

Our bioanalytical platform supports your preclinical and clinical stages with expert testing services.

CMC regulatory services

Our comprehensive CMC regulatory services streamline the preparation and submission of the regulatory files for your nanomedicines.