Selecting the right solid form early can significantly reduce risk in solid oral drug development. In this application note, Ardena shares a case study demonstrating how comprehensive experimental polymorph screening, combined with structural informatics using crystal structure database insights, supports confident selection of the most thermodynamically stable polymorph. The approach strengthens development decisions by balancing stability, processability, and performance from the start.

Mechanochemistry offers a powerful alternative to traditional stress testing, accelerating degradation studies while revealing more relevant impurity profiles.
In collaboration with RD&C Research, Ardena explores how solid-state stress testing using mechanochemistry enables faster, solvent-free degradation of APIs and formulations, supporting more predictive stability assessments.

Read our latest application note featuring a case study on Ibuprofen.

Polymorph screening is a key step in drug development, impacting solubility, stability, and bioavailability. In collaboration with ELDICO Scientific, we explore how electron diffraction enhances the identification of minor polymorphs, ensuring a deeper understanding of solid form landscapes.

Read our latest application note featuring a case study on Aripiprazole.