Ardena, a specialist pharmaceutical contract development and manufacturing organisation (CDMO), has applied its considerable expertise in drug substance development to assist IRLAB of Gothenburg, Sweden, in taking mesdopetam, an oral dopamine D3-receptor antagonist, from pre-clinical up to its phase I and II clinical programs.
This success has led to a licensing agreement for phase III and worldwide commercialization of mesdopetam1, a potential treatment for people living with Parkinson’s diseaseand experiencing levodopa-induced dyskinesia. Mesdopetam is also in early development for Parkinson’s Disease Psychosis (PDP), which is a common symptom of PD.
“We are delighted to have supported IRLAB get investigational mesdopetam to the next phase. Having guided the entire process up to both pre-clinical and GMP scale, as well as supporting the IMPD submissions in different countries, we can now look forward to Phase III,” said Agnese Jurkevica, Site Director, Ardena, Riga. “The positive data we have generated through our successful collaboration has been key to getting this investigational compound a step closer to helping people living with the effects of Parkinson’s disease.”
Mesdopetam (IRL790) is a dopamine D3-receptor antagonist being designed to prevent and treat levodopa-induced dyskinesias (LIDs), a severe form of involuntary movements common in sufferers of Parkinson’s disease (PD). Clinical studies have shown that mesdopetam reduces the dyskinesia increasing good daily ‘On-Time’ for patients. It has also shown antipsychotic properties in preclinical studies.
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About Ardena Group
The Ardena Group (’Ardena’) is a world-class Contract Development and Manufacturing Organization. Ardena assists pharmaceutical companies, from virtual biotech to big pharma, in bringing their valued molecules to the clinic and the market.
Ardena provides a comprehensive range of services from early drug substance development to finished dosage form, including: drug substance development & manufacturing; solid state research; drug product development & manufacturing; drug product packaging, labelling & supply; bioanalysis; dossier development and nanomedicine. For more information, please visit https://ardena.com/
IRLAB, based in Gothenburg, Sweden, is dedicated to the discovery and development of new drugs for treatment of Parkinson’s disease and other life-altering diseases that affect the central nervous system. They strive to transform the everyday life for patients who lack effective treatment options through their unique proprietary research platform ISP – Integrative Screening Process. The platform enables discovery and development of therapeutic candidates for diseases related to the central nervous system. For more information, please visit https://irlab.se/