The bulk properties of a powder have a huge impact on the downstream processing properties (filterability, dryability, flowability, etc) or formulation (bulk density, impurities, etc) of a drug substance. Having control of the crystallisation process is essential in order to consistently obtain material with the desired properties.
At Ardena, we have the systems and equipment to help our customers understand and control crystallisation processes and thus gain insight into how to improve yield, control particle size and habit, and reduce process time.
Emphasis is given to investigating the compound’s crystallisation behaviour and identifying the parameters influencing such behaviour. We have the capabilities to perform experiments at a scale of a few ml up to a maximum of 4 litres.
We work closely with our customers’ process development or pilot plant groups in order to optimise the relevance and effectiveness of the research project and then facilitate efficient technology transfer.