If you’re facing solubility challenges that impact your drug candidate’s reproducible absorption from the gastrointestinal tract after oral administration, Ardena can help. In such cases where poor API solubility is limiting oral bioavailability, formulation techniques can be applied to increase the dissolution rate and/or apparent solubility at the site of absorption.
Ardena offers solubility-enhancing methods and technologies, including:
- Amorphous solid dispersions
- Lipid-based formulations
Rather than an empirical exploration of all solubilisation technologies, we use a science-based approach to select the most appropriate formulation strategy for your compound.
For all solubility-enhancing technologies, screening platforms are in place which enable the identification of performant formulation concepts with minimum API consumption. The processes to produce these concepts are then developed in our formulation laboratory and finally transitioned into our GMP-production facility.